Cephalosporin coverage Mnemonic, Anaerobes

1st Gen	Gram (+) cocci Staph, Strep
	Gram (-) rods PEcK  P-roteus, E - coli, K -lebsiella pneumoniae
2nd Gen	Gram (+) cocci Staph, Strep
	Gram (-) rods HENPEcK  H - Influenzae, E - nterobacter aerogenes N - eisseria gonorrhea P-roteus, E - coli, K -lebsiella pneumoniae
3rd Gen	Gram (+) cocci Strep
	Gram (-) rods HENPEcK + P* H - Influenzae, E - nterobacter aerogenes N - eisseria gonorrhea P-roteus, E - coli, K -lebsiella pneumoniae P - seudomonas aureginosa (For some 3rd Gen)

Content: 4 🏅🏅🏅🏅 (Must-know)

Ease of memorisation: Very poor, requires repeated memorisation

Source: Lippincott

ABC of Anaerobes
Common Anaerobes

A - Actinomyces
B - Bacteroides Fragilis
C - Clostrodium sp.






Additional Notes:

3rd Gen cephalosporins: increased spectrum of activity against gram-negative bacteria, moderate activity against anaerobic bacteria, and reduced anti-gram-positive activity as compared with earlier cephalosporins

Cefoxitin 
Indication: Surgical Prophylaxis

Cefoxitin was the most active against 33 isolates of Bacteroides fragilis

Citations
Tally, F. P., Jacobus, N. V., Bartlett, J. G., & Gorbach, S. L. (1975). Susceptibility of anaerobes to cefoxitin and other cephalosporins. Antimicrobial agents and chemotherapy, 7(2), 128–132. doi:10.1128/aac.7.2.128